14th Charles Brupbacher Symposium 2019

The following Scientific Symposium will take place at the ETH Swiss Federal Institute of Technology, Rämistrasse 101, Audi Max (HG F 30)



19:00 – 20:00

Charles Rodolphe Brupbacher

Anne Müller: Mikrobielle Infektionen als Ursache von Krebs
Public Event 


12:00 – 13:30

Registration and Sandwich Lunch

13:30 – 15:00

Cancer Cell Heterogeneity

Chair: Lukas Sommer
Andreas Trumpp: A single cell view on stem cells and cancer

Alain Puisieux: Cellular pliancy and breast cancer heterogeneity

Nicola Aceto: Heterogeneity and vulnerabilities of circulating tumor cells

15:00 – 15:30

Coffee break

15:30 – 17:30

Genetics and Epigenetics

Chair: Lauri Aaltonen
Peter Lichter: From (epi) genomic profiling to clinical applications

Jean-Philippe Theurillat: Towards the understanding of genetically-defined subtypes of prostate cancer

Nada Jabado: Oncohistones: how to turn the cell's symphony into non-harmonic rap
G. Steven Bova: Evolution of lethal prostate cancer at primary and metastatic sites: Can we identify what is important?

17.45 – 20:45

Posters, Beer and Pretzels


08:00 – 08:30


08:30 – 10:00

Big data in Epidemiology and Cancer Research

Chair: Sir Alex Markham
Richard J. Gilbertson: Multi-organ mapping of cancer origins
Ian Tomlinson: Inherited factors that influence cancer risk and behaviour

Serena Nik-Zainal: Insights from cancer genome sequencing: Utilising the totality of mutagenesis for clinical purposes

10:00 – 10:30

Coffee break

10:30 – 12:00

Signaling pathways in response & resistance to cancer therapy

Chair: Nancy Hynes
Mike Hall: Mechanisms of Evasive Resistance in HCC

Daniel S. Peeper: Towards rational combinatorial cancer treatment – a functional genomics approach

Gerhard Christofori: Regulatory circuits in EMT, cell plasticity and cancer metastasis

12:00 – 13:30

Lunch + Coffee + Posters

13:30 – 15:00

Cancer metabolism/autophagy

Chair: Josef Jiricny
Sean Morrison: Lactate exchange promotes oxidative stress resistance and melanoma metastasis
Pierre Close: Codon-specific mRNA translation regulation in cancer
Matthew Vander Heiden: Role of metabolism in supporting tumor progression

15:00 – 15:30


15:30 – 17:00

Tumour Microenvironment and Metastasis

Chair: Miriam Merad
Karin de Visser: Dissecting tumor-genotype/immunophenotype relationships in metastatic breast cancer
Johanna Joyce: Exploring and exploiting the tumour microenvironment
Paul Frenette: Cancer regulation by the bone marrow microenvironment

17:15 – 18:30

Award Ceremony Charles Rodolphe Brupbacher Prize for Cancer Research 2019

Public Event


08:30 – 10:00

Breakthroughs in Cancer Therapy

Chair: Markus Manz
Antoni Ribas: Overcoming resistance to PD-1 blockade therapy
Andrew W. Roberts: Targeting BCL2 as therapy for haematological malignancies: from  concept to emerging clinical applications
Peter Hillmen: Curing CLL: A glimpse into the future of cancer treatment?

10:00 – 10:30

Coffee break

10:30 – 11:30 

Breakthroughs in Cancer Biology

Chair: Holger Moch
Bernd Bodenmiller: Highly multiplexed analysis of tissue ecosystems using imaging mass cytometry
Nicola Valeri: Patient-derived organoids: promises, hurdles and potential clinical applications

11:30 – 12:00

Award Ceremony Young Investigator Award

Public Event


End of Meeting