19:00 – 20:00
Charles Rodolphe Brupbacher
Anne Müller: Mikrobielle Infektionen als Ursache von Krebs
Public Event
12:00 – 13:30
Registration and Sandwich Lunch
13:30 – 15:00
Cancer Cell Heterogeneity
Chair: Lukas Sommer
Andreas Trumpp: A single cell view on stem cells and cancer
Alain Puisieux: Cellular pliancy and breast cancer heterogeneity
Nicola Aceto: Heterogeneity and vulnerabilities of circulating tumor cells
15:00 – 15:30
Coffee break
15:30 – 17:30
Genetics and Epigenetics
Chair: Lauri Aaltonen
Peter Lichter: From (epi) genomic profiling to clinical applications
Jean-Philippe Theurillat: Towards the understanding of genetically-defined subtypes of prostate cancer
Nada Jabado: Oncohistones: how to turn the cell's symphony into non-harmonic rap
G.
G. Steven Bova: Evolution of lethal prostate cancer at primary and metastatic sites: Can we identify what is important?
17.45 – 20:45
Posters, Beer and Pretzels
08:00 – 08:30
Registration
08:30 – 10:00
Big data in Epidemiology and Cancer Research
Chair: Sir Alex Markham
Richard J. Gilbertson: Multi-organ mapping of cancer origins
Ian Tomlinson: Inherited factors that influence cancer risk and behaviour
Serena Nik-Zainal: Insights from cancer genome sequencing: Utilising the totality of mutagenesis for clinical purposes
10:00 – 10:30
Coffee break
10:30 – 12:00
Signaling pathways in response & resistance to cancer therapy
Chair: Nancy Hynes
Mike Hall: Mechanisms of Evasive Resistance in HCC
Daniel S. Peeper: Towards rational combinatorial cancer treatment – a functional genomics approach
Gerhard Christofori: Regulatory circuits in EMT, cell plasticity and cancer metastasis
12:00 – 13:30
Lunch + Coffee + Posters
13:30 – 15:00
Cancer metabolism/autophagy
Chair: Josef Jiricny
Sean Morrison: Lactate exchange promotes oxidative stress resistance and melanoma metastasis
Pierre Close: Codon-specific mRNA translation regulation in cancer
Matthew Vander Heiden: Role of metabolism in supporting tumor progression
15:00 – 15:30
Coffeebreak
15:30 – 17:00
Tumour Microenvironment and Metastasis
Chair: Miriam Merad
Karin de Visser: Dissecting tumor-genotype/immunophenotype relationships in metastatic breast cancer
Johanna Joyce: Exploring and exploiting the tumour microenvironment
Paul Frenette: Cancer regulation by the bone marrow microenvironment
17:15 – 18:30
Award Ceremony Charles Rodolphe Brupbacher Prize for Cancer Research 2019
Public Event
08:30 – 10:00
Breakthroughs in Cancer Therapy
Chair: Markus Manz
Antoni Ribas: Overcoming resistance to PD-1 blockade therapy
Andrew W. Roberts: Targeting BCL2 as therapy for haematological malignancies: from concept to emerging clinical applications
Peter Hillmen: Curing CLL: A glimpse into the future of cancer treatment?
10:00 – 10:30
Coffee break
10:30 – 11:30
Breakthroughs in Cancer Biology
Chair: Holger Moch
Bernd Bodenmiller: Highly multiplexed analysis of tissue ecosystems using imaging mass cytometry
Nicola Valeri: Patient-derived organoids: promises, hurdles and potential clinical applications