Young Investigator Award

The Charles Rodolphe Brupbacher Foundation bestows a biennial prize to young investigators who contributed to the Scientific Symposium.

Laureates 2017

Júlia Aguadé-Gorgorió
Zurich, Switzerland
TNF receptor 2 regulates RIP1-dependent cell death in refractory leukemia

Natalia Arenas-Ramirez
Zurich, Switzerland
Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2

Anna C. Groner
Basel, Switzerland
TRIM24 is an oncogenic transcriptional activator in prostate cancer

Karina Silina
Zurich, Switzerland
Germinal centers underlie the prognostic benefit of tertiary lymphoid structures in lung squamous cell carcinoma patients and are negatively affected by steroids

Anna Stelling
Zurich, Switzerland
Tumor suppressive mechanisms of S1PR2 signaling in DLBCL

From left: Georg C. Umbricht, Anna Stelling, Karina Silina, Anna C. Groner, Júlia Aguadé-Gorgorió, Natalia Arenas-Ramirez, Nancy Hynes

Laureates 2015

Michael Kiessling
Zurich, Switzerland  
Mutant HRAS activates RAS and mTOR signaling and sensitizes to MEK and mTOR inhibitors

Hella A. Bolck
Zurich, Switzerland  
A novel connection between CtIP and BRCA1/BARD1 emerges through functional RNAi screening

Jan Pencik
Vienna, Austria  
Aberrant STAT3-ARF signaling targets distinct subgroups of lethal prostate cancer

Phil F. Cheng
Zurich, Switzerland  
Data mining The Cancer Genome Atlas

Christian M. Schürch
Carsten Riether

Bern, Switzerland  
CD70/CD27-signaling is an independent adverse prognostic marker and novel therapeutic target for acute myelogenous leukemia

From left: Michael Kiessling, Hella A. Bolck, Jan Pencik, Phil F. Cheng, Christian M. Schürch

Laureates 2013

Daniel Zingg
Zurich, Switzerland
Role of the epigenetic modifier EZH2 in melanoma

Sabine Gruber
Cologne, Germany
Obesity-associated inflammation promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6 signaling

Gregory Driessens
Brussels, Belgium
Defining the mode of tumour growth by clonal analysis

Angelos Papaspyropoulos
Oxford, United Kingdom
RASSF1A loss deregulates hippo pathway signalling in tumourigenesis

Adrian Britschgi
Basel, Switzerland
JAK2/STAT5 inhibition circumvents resistance to PI3K/mTOR blockade: a rationale for cotargeting these pathways in metastatic breast cancer

From left: Klaus W. Grätz (Dean of the Medical Faculty), Daniel Zingg, Sabine Gruber, Gregory Driessens, Angelos Papaspyropoulos, Adrian Britschi, Georg Umbricht (Member of the Foundation Board)

Laureates 2011

Stefan Ch. Metzler
Jean-Philippe Theurillat

Zurich, Switzerland   
Disruption of a negative feedback loop promotes growth factor independence and chemotherapy resistance in ovarian cancer

Vanessa J. Craig
Zurich, Switzerland
MicroRNA deregulation in gastric MALT lymphoma

Kanagaraj Radhakrishnan
Zurich, Switzerland
Identification of the Werner syndrome protein as a novel member of the error-free 8-oxo-guanine bypass pathway

Svetlana Khoronenkova
Oxford, United Kingdom
Phosphorylation-dependent regulation of a specific USP7 isoform controls Mdm2 and p53 levels in response to DNA damage

Daniel Cortázar
Basel, Switzerland
Embryonic lethality of Tdg deficient mice reveals a function of DNA repair in the maintenance of epigenetic stability

From left: Daniel Cortázar, Svetlana Khoronenkova, Kanagaraj Radhakrishna, Mme Frédérique Brupbacher (Founder), Klaus W. Grätz (Dean of the Medical Faculty), Vanessa J. Craig, Stefan Ch. Metzler, Jean-


Johannes Haybaeck
Zurich, Switzerland
A lymphotoxin driven pathway to chronic hepatitis and hepatocellular carcinoma

Laura Bonapace
Zurich, Switzerland
Induction of autophagy-dependent cell death is required to restore steroid sensitivity in steroid-resistant ALL

Andreas Wicki
Basel, Switzerland
Glucagon-like-peptide-1 (GLP-1) receptor as a new diagnostic and therapeutic target in human insulinoma

Claudio R. Thoma
Zurich, Switzerland
VHL loss causes spindle mis-orientation and chromosome instability

Michele Teng
Victoria, Australia
Combined NKT-cell based immunotherapy eradicates established tumors in mice

Sara Colombetti
Lausanne, Switzerland
Lentivector immunizations elicit sustained and long lasting tumor antigenspecific CD8+ T cell responses

Ataman Sendoel
Zurich, Switzerland
HIF-1 antagonizes DNA damage-induced apoptosis

Gunther Boysen
Zurich, Switzerland
Identification of VHL-regulated cell membrane proteins in renal cell carcinoma using tandem mass spectrometry

Peter J. Wild
Zurich, Switzerland
Loss of expression of the ATP-bindig cassette (ABC) transporter protein ABCA3 may predict tumor recurrence in patients with breast cancer

Ulrich auf dem Keller
Zurich, Switzerland
Nrf Transcription Factors are Crucial for Skin Tumor Prevention but not for Wound Healing

Melanie Blasius
Zurich, Switzerland
Deinococcus Radiodurans: An Extraordinarily Radio Resistant Organism as a Model to Understand Double Strand Break Repair

Patrick Garcia
Zurich, Switzerland
Human RECQ5beta, a Protein with DNA Helicase and Strand-Annealing Activities in a Single Polypeptide

Katarina Hajdin
Zurich, Switzerland
Targeting of Pediatric Embryonal Tumors

Armelle Yart
Zurich, Switzerland
The HRPT2 Tumor Suppressor Gene Product Parafibromin Associates with Human PAF1 and RNA Polymerase II